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Zanaflex

Generic: Tizanidine Hydrochloride

Rx only
Central alpha-2-adrenergic agonist✓ FDA-verified
View full FDA label ↗
Zanaflex is a medication used to help manage muscle stiffness and spasms, particularly in conditions like multiple sclerosis or spinal cord injury. It works by calming the nerves that control muscle movement, which helps reduce tightness. You typically start with a dose of 2 mg, which can be taken up to three times a day, but you should not exceed a total of 36 mg in one day. It's important to know that Zanaflex should not be taken with certain medications like fluvoxamine or ciprofloxacin, as these can significantly increase its effects and side effects. Additionally, if you have kidney problems, you may need a lower dose, so it's essential to talk to your doctor about your health conditions.

Uses

  • Management of spasticity.

Dosage

Starting dose is 2 mg.
Can be repeated every 6 to 8 hours.
Maximum of 3 doses in 24 hours.
Total daily dose should not exceed 36 mg.
Take with or without food, but be consistent.
Always follow your doctor's specific instructions for your dose.

Side effects

Common

dry mouthdrowsinessweaknessdizziness

Serious

liver injuryhallucinationssevere hypotension
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Warnings

⚠ Important warnings

  • Use with caution in patients with liver impairment.
  • Use with caution in patients with kidney issues.
  • Avoid using with fluvoxamine or ciprofloxacin.
  • Monitor for hypotension and excessive drowsiness.

Drug interactions

  • Fluvoxamineincreases drowsiness and lowers blood pressureMonitor
  • Ciprofloxacinincreases drowsiness and lowers blood pressureMonitor
  • Alcoholincreases side effects and sedationMonitor
  • Oral contraceptiveslowers clearance of tizanidine.Caution

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Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).