MedDataToolAllopurinol is a medication used to treat conditions like gout, certain types of cancer, and recurrent kidney stones caused by high uric acid levels. It works by reducing the amount of uric acid your body produces, helping to prevent painful flare-ups and complications. You typically take it as a tablet, starting with a dose of 100 mg daily, which can be increased weekly up to a maximum of 800 mg daily, depending on your needs and kidney function. It's important to know that if you have ever had an allergic reaction to allopurinol, you should not take this medication. Additionally, be cautious if you are taking mercaptopurine or azathioprine, as allopurinol can increase their effects and lead to more side effects.
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Uses
- Management of gout in adults.
- Management of leukemia in adults and children.
- Management of lymphoma in adults and children.
- Management of solid tumor malignancies in adults and children.
- Management of recurrent calcium oxalate calculi in adults.
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Dosage
Initial dose for gout is 100 mg daily, increasing weekly.
For cancer therapy, adults take 300–800 mg daily.
Pediatric patients take 100 mg/m² every 8 to 12 hours.
For recurrent calcium oxalate stones, start with 200–300 mg daily.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
nauseadiarrheaskin rash
Serious
increased liver enzymesnephrotoxicityhepatotoxicitymyelosuppression
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Warnings
⚠ Important warnings
- Not for asymptomatic hyperuricemia treatment.
- Monitor kidney function during treatment.
- Risk of severe skin reactions with certain drugs.
- Use caution in patients with renal impairment.
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Drug interactions
- Capecitabinemay decrease effectivenessCaution
- Mercaptopurineincreases risk of adverse reactionsMonitor
- Azathioprineincreases risk of adverse reactionsMonitor
- Pegloticasemay increase risk of anaphylaxisCaution
- Thiazide diureticsmay increase allopurinol toxicity.Caution
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).