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Alprazolam

Rx only
Benzodiazepines✓ FDA-verified
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Alprazolam is a medication used to treat anxiety and panic disorders in adults. It works by enhancing the effects of a natural calming substance in the brain, helping to reduce feelings of anxiety and panic. You typically take it as a tablet, starting with a dose of 0.25 mg to 0.5 mg three times a day for anxiety, or 0.5 mg three times a day for panic disorder, with a maximum dose of 4 mg per day. It's important to know that alprazolam can cause dependence, so it's crucial to follow your doctor's instructions carefully. Additionally, if you are taking strong medications that affect liver enzymes, like ketoconazole or itraconazole, you should avoid using alprazolam, as this can lead to serious side effects.

Uses

  • generalized anxiety disorder in adults. panic disorder in adults.

Dosage

For generalized anxiety disorder: start with 0.25 mg to 0.5 mg three times daily.
For panic disorder: start with 0.5 mg three times daily.
Dosage may be increased every 3 to 4 days based on response.
Maximum daily dose is 4 mg, divided into multiple doses.
Always follow your doctor's specific instructions for your dose.

Side effects

Common

drowsinesslight-headednessdizzinessdry mouthimpaired coordinationrespiratory depression

Serious

dependencewithdrawal reactionsseizures
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Warnings

⚠ Important warnings

  • Risk of severe sedation and respiratory depression when used with opioids.
  • Potential for abuse, misuse, and addiction.
  • Withdrawal symptoms can be life-threatening if stopped abruptly.
  • Use caution in elderly patients and those with liver impairment.

Drug interactions

  • Opioidsincreases risk of respiratory depressionMonitor
  • CNS depressantsadditive effects can cause sedationCaution
  • Digoxinincreases risk of digoxin toxicityMonitor
  • Strong CYP3A inhibitorsincreases alprazolam levels and side effectsMonitor
  • CYP3A inducersmay reduce effectiveness of alprazolam.Caution

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Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).