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Azacitidine

Generic: Azacitidine For

Rx only
Nucleoside metabolic inhibitor✓ FDA-verified
View full FDA label ↗
Azacitidine is a medication used to treat certain types of blood disorders, including myelodysplastic syndromes and chronic myelomonocytic leukemia. It works by targeting and killing abnormal blood cells in the bone marrow, helping to restore normal blood cell production. The medication is given as an injection, with a starting dose of 75 mg per square meter of body surface area daily for seven days, and it can be increased to a maximum of 100 mg if needed. It is important to know that azacitidine should not be used in patients with advanced liver cancer or those who are allergic to it or its ingredients. Additionally, patients with kidney problems may need careful monitoring, as the medication is processed by the kidneys.
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Uses

  • Refractory anemia (RA).
  • Refractory anemia with ringed sideroblasts (RARS).
  • Refractory anemia with excess blasts (RAEB).
  • Refractory anemia with excess blasts in transformation (RAEB-T).
  • Chronic myelomonocytic leukemia (CMMoL).
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Dosage

75 mg/m² daily for 7 days by injection.
Repeat cycles every 4 weeks.
Increase to 100 mg/m² if no benefit after 2 cycles.
Monitor blood counts and adjust as needed.
Always follow your doctor's specific instructions for your dose.
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Side effects

Common

nauseavomitinganemiathrombocytopeniadiarrheainjection site reactionsneutropenia

Serious

renal toxicityhepatotoxicitytumor lysis syndrome
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Warnings

⚠ Important warnings

  • Do not substitute for oral azacitidine.
  • Monitor renal function in elderly patients.
  • Risk of toxic reactions in patients with kidney issues.
  • Reduce dose if serum bicarbonate or creatinine levels are abnormal.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).