MedDataToolBrexpiprazole is a medication used to help treat major depressive disorder when combined with antidepressants, schizophrenia in adults and teens aged 13 and older, and agitation related to Alzheimer's disease. It works by affecting certain brain chemicals to help improve mood and reduce symptoms of these conditions. You take it as a pill once a day, starting with a dose of 0.5 mg to 1 mg, which can be increased to a maximum of 3 mg for depression or agitation, and up to 4 mg for schizophrenia. It's important to know that this medication is not suitable for anyone who has had a severe allergic reaction to it or its ingredients. Additionally, if you are taking strong CYP2D6 inhibitors, like certain antidepressants, your doctor may need to adjust your dose.
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Uses
- Major depressive disorder in adults.
- Schizophrenia in adults and patients ages 13 and older.
- Agitation associated with dementia due to Alzheimer's disease.
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Dosage
Adults with major depressive disorder: Start at 0.5 or 1 mg, target 2 mg daily.
Adults with schizophrenia: Start at 1 mg, target 2 to 4 mg daily.
Pediatric patients (13-17 years) with schizophrenia: Start at 0.5 mg, target 2 to 4 mg daily.
Agitation in dementia: Start at 0.5 mg, target 2 mg daily.
Take once daily with or without food.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Weight gainsleepinessrestlessnessheadache
Serious
Increased risk of death in elderly with dementiasuicidal thoughtsstroke
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Warnings
⚠ Important warnings
- Increased mortality in elderly patients with dementia-related psychosis.
- Risk of suicidal thoughts in young adults and adolescents.
- Not approved for dementia-related psychosis without agitation.
- Monitor for worsening symptoms in patients taking antidepressants.
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Drug interactions
- Strong CYP3A4 inhibitorsreduce REXULTI dosageCaution
- Strong CYP2D6 inhibitorsmay not need dosage adjustmentCaution
- Both CYP3A4 and CYP2D6 inhibitorsreduce REXULTI dosageCaution
- Strong CYP3A4 inducersincrease REXULTI dosage.Caution
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).