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Chlorpromazine

Generic: Chlorpromazine Hydrochloride

Rx only
Antipsychotic✓ FDA-verified
View full FDA label ↗
Chlorpromazine is a medication used to treat conditions like schizophrenia, severe nausea, and certain behavioral problems in children. It works by affecting the brain's chemicals to help improve mood and reduce agitation. The medication is usually taken in tablet form, starting with a dose of 25 mg to 50 mg taken three to four times a day, and can be increased based on your doctor's advice, with a maximum dose that can reach up to 2,000 mg per day for some patients. It's important to know that this medication should not be used if you are in a coma or taking large amounts of alcohol or other central nervous system depressants. Additionally, chlorpromazine may interact with medications that lower blood pressure, so it's crucial to inform your doctor about all the medications you are taking.
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Uses

  • Management of psychotic disorders.
  • Treatment of schizophrenia.
  • Control of nausea and vomiting.
  • Relief of restlessness before surgery.
  • Treatment of acute intermittent porphyria.
  • Adjunct treatment for tetanus.
  • Control of manic symptoms in manic-depressive illness.
  • Relief of intractable hiccups.
  • Treatment of severe behavioral problems in children (1 to 12 years).
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Dosage

Adults: Adjust based on individual needs and severity.
Elderly: Lower dosages are usually sufficient.
Nausea and vomiting: 10 to 25 mg every 4 to 6 hours as needed.
Presurgical apprehension: 25 to 50 mg 2 to 3 hours before surgery.
Children: ¼ mg/lb body weight every 4 to 6 hours as needed.
Always follow your doctor's specific instructions for your dose.
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Side effects

Common

Drowsinessjaundicedry mouthnasal congestionAgranulocytosis

Serious

tardive dyskinesianeuroleptic malignant syndromesevere hypotension
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Warnings

⚠ Important warnings

  • Increased risk of death in elderly patients with dementia-related psychosis.
  • Not approved for dementia-related psychosis treatment.
  • Risk of tardive dyskinesia with long-term use.
  • Monitor for signs of neuroleptic malignant syndrome.
  • Use cautiously in patients with liver disease.
  • Avoid alcohol due to increased sedation.
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Drug interactions

  • Guanethidinemay reduce its blood pressure effectCaution

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).