MedDataToolClobazam is a medication used to help treat seizures associated with Lennox-Gastaut syndrome in patients who are 2 years old or older. It works by enhancing the effects of a natural calming substance in the brain, which helps reduce seizure activity. The medication comes as an oral suspension and is usually taken once or twice a day, starting at 5 mg for patients weighing 30 kg or less, and 10 mg for those over 30 kg, with a maximum dose of 20 mg or 40 mg daily, depending on weight. It's important to know that clobazam should not be taken by anyone who has had a serious allergic reaction to it or its ingredients. Additionally, if you are taking strong medications that affect liver enzymes, such as ketoconazole, you may need a dose adjustment while using clobazam.
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Uses
- Seizures associated with Lennox-Gastaut syndrome in patients 2 years and older.
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Dosage
For patients ≤30 kg: Start at 5 mg daily, increase to 20 mg daily as tolerated.
For patients >30 kg: Start at 10 mg daily, increase to 40 mg daily as tolerated.
Doses above 5 mg/day should be split into two doses.
Can be taken with or without food.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
ConstipationsomnolencelethargydroolingpyrexiaDependence
Serious
withdrawal reactionssuicidal behaviorserious skin reactions
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Warnings
⚠ Important warnings
- Risk of severe sedation and respiratory depression when used with opioids.
- Potential for abuse, misuse, and addiction.
- Risk of withdrawal reactions if stopped suddenly.
- Use cautiously in elderly patients and those with liver impairment.
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Drug interactions
- Opioidsincreased risk of respiratory depressionMonitor
- Alcoholincreases blood levels of clobazam by 50%Monitor
- CYP2D6 drugsmay need lower dosesCaution
- Strong CYP2C19 inhibitorsmay require dosage adjustments.Caution
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).