MedDataToolDapagliflozin is a medication used to help manage conditions like chronic kidney disease, heart failure, and type 2 diabetes. It works by helping your kidneys remove excess sugar from your blood through urine, which can also lower blood pressure and reduce strain on the heart. You typically take it as a pill once a day, starting with 10 mg, and it can be increased to a maximum of 20 mg if needed. It's important to know that this medication is not recommended for people with a serious allergy to it or for those with type 1 diabetes. Additionally, if you are taking insulin or certain other diabetes medications, you may need to be cautious as it can increase the risk of low blood sugar.
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Uses
- Chronic kidney disease at risk of progression.
- Heart failure.
- Type 2 diabetes with cardiovascular disease.
- Type 2 diabetes with multiple cardiovascular risk factors.
- To improve glycemic control in type 2 diabetes.
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Dosage
5 mg once daily for glycemic control if eGFR 45 or greater. 10 mg once daily for other indications if eGFR 45 or greater. 10 mg once daily if eGFR 25 to less than 45.
Not recommended for initiation if eGFR less than 25.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Female genital mycotic infectionsNasopharyngitisUrinary tract infectionsIncreased urinationDiabetic ketoacidosis in type 1 diabetes
Serious
Severe hypoglycemia with insulin use
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Warnings
⚠ Important warnings
- Not recommended for type 1 diabetes.
- Not recommended for eGFR less than 45 mL/min/1.73 m².
- Not recommended for chronic kidney disease with polycystic kidney disease.
- Monitor for volume depletion before starting.
- Withhold before major surgery.
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Drug interactions
- Insulinincreased risk of hypoglycemiaMonitor
- Insulin secretagoguesincreased risk of hypoglycemiaMonitor
- Lithiummay decrease serum lithium concentrationsCaution
- Urine glucose testsmay give false positive results. 1,5-anhydroglucitol assay — unreliable for monitoring glycemic controlMonitor
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).