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Desvenlafaxine

Generic: Desvenlafaxine Succinate

Rx only
SNRIAlso: Pristiq Extended-Release✓ FDA-verified
View full FDA label ↗
Desvenlafaxine, also known as Pristiq, is a medication used to treat major depressive disorder in adults. It works by increasing the levels of certain chemicals in the brain that help improve mood. You should take it as a tablet, swallowing it whole, once a day, starting with a dose of 50 mg, which is also the maximum dose for most people. It's important to know that you should not take this medication if you are allergic to it or similar medications, and you should avoid using it with certain antidepressants called MAOIs, as this can lead to serious side effects.
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Uses

  • major depressive disorder (MDD).
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Dosage

Take 50 mg once daily, with or without food.
Do not exceed 50 mg per day for most patients.
For severe renal impairment, maximum dose is 25 mg daily or 50 mg every other day.
For moderate to severe liver impairment, maximum dose is 100 mg daily.
Always follow your doctor's specific instructions for your dose.
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Side effects

Common

nauseadizzinessinsomniahyperhidrosisconstipationsomnolencedecreased appetiteanxiety

Serious

suicidal thoughtsserotonin syndromeelevated blood pressureincreased risk of bleeding
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Warnings

⚠ Important warnings

  • Increased risk of suicidal thoughts and behaviors in young adults.
  • Not approved for use in children.
  • Monitor closely for worsening symptoms.
  • Avoid use with MAOIs to prevent serotonin syndrome.
  • Use caution with anticoagulants due to bleeding risk.
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Drug interactions

  • MAOIsincreased risk of serotonin syndromeMonitor
  • Linezolidrisk of serotonin syndromeCaution
  • NSAIDsincreased risk of bleedingMonitor
  • Aspirinincreased risk of bleedingMonitor
  • Warfarinincreased risk of bleeding.Monitor

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).