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Eplerenone

Rx only
Aldosterone AntagonistAlso: Inspra✓ FDA-verified
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Eplerenone is a medication used to improve survival in adults with heart failure after a heart attack and to lower high blood pressure. It works by blocking a hormone that can cause the body to retain salt and water, which helps reduce blood pressure and strain on the heart. You typically start with a dose of 25 mg once daily for heart failure, which can be increased to a maximum of 50 mg once daily, while for high blood pressure, the starting dose is 50 mg once daily, which can be increased to 50 mg twice daily if needed. It's important to know that eplerenone should not be taken if your potassium levels are too high, as this can lead to serious health issues. Additionally, if you are taking strong CYP3A inhibitors, like ketoconazole, your dose may need to be adjusted to avoid increased side effects.

Uses

  • Heart failure with reduced ejection fraction after a heart attack.
  • High blood pressure in adults.

Dosage

Start with 25 mg once daily for heart failure, increase to 50 mg as tolerated.
For high blood pressure, start with 50 mg once daily.
If blood pressure is not controlled, increase to 50 mg twice daily.
Monitor potassium levels before starting and during treatment.
Always follow your doctor's specific instructions for your dose.

Side effects

Common

high potassium levelsincreased creatininekidney problems

Serious

severe allergic reactions
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Warnings

⚠ Important warnings

  • Risk of high potassium levels, especially with kidney issues.
  • Use caution with ACE inhibitors and angiotensin II blockers.
  • Monitor potassium and kidney function, especially in the elderly.

Drug interactions

  • CYP3A Inhibitorsmay increase eplerenone levelsCaution
  • ACE Inhibitorsincreased risk of high potassiumMonitor
  • NSAIDsmay reduce blood pressure effect.Caution

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).