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Famotidine

Rx only
Histamine-2 receptor antagonist✓ FDA-verified
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Famotidine is a medication used to treat conditions like active ulcers in the stomach and intestines, gastroesophageal reflux disease (GERD), and certain conditions that cause excessive stomach acid. It works by reducing the amount of acid your stomach produces, helping to relieve symptoms and promote healing. You typically take it as a tablet, either once daily before bedtime or twice daily, with a common starting dose of 20 mg to 40 mg, depending on your condition, and the maximum dose can go up to 160 mg every six hours for specific cases. It's important to know that famotidine should not be used if you have had a serious allergic reaction to it or similar medications. Additionally, if you are taking probenecid, a medication that affects kidney function, it may increase the levels of famotidine in your body, so be sure to discuss this with your doctor.

Uses

  • active duodenal ulcer. active gastric ulcer. symptomatic nonerosive gastroesophageal reflux disease (GERD). erosive esophagitis due to GERD. pathological hypersecretory conditions. reduction of the risk of duodenal ulcer recurrence.

Dosage

  • 40 mg once daily for active duodenal ulcer. 40 mg once daily for active gastric ulcer. 20 mg twice daily for GERD. 20 mg twice daily for erosive esophagitis. 20 mg every 6 hours for pathological hypersecretory conditions. 20 mg once daily for risk reduction of duodenal ulcer recurrence.
  • Take before bedtime or twice daily with or without food.

Side effects

Common

headachedizzinessconstipationdiarrheaarrhythmia

Serious

anaphylaxisconfusiontoxic epidermal necrolysis
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Warnings

⚠ Important warnings

  • Use caution in patients with renal impairment.
  • Avoid use with tizanidine due to increased blood concentration risks.
  • May reduce absorption of drugs that depend on gastric pH.

Drug interactions

  • Dasatinibreduced absorption effectivenessCaution
  • Delavirdine mesylatereduced absorption effectivenessCaution
  • Cefditorenreduced absorption effectivenessCaution
  • Fosamprenavirreduced absorption effectivenessCaution
  • Tizanidinerisk of hypotension and excessive drowsinessCaution

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Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).