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Invokamet Xr

Generic: Canagliflozin And Metformin Hydrochloride

Rx only
SGLT2 inhibitorAlso: INVOKAMET✓ FDA-verified
View full FDA label ↗
Invokamet XR is a medication used to help control blood sugar levels in adults and children aged 10 years and older with type 2 diabetes. It combines two active ingredients that work together: one helps your body get rid of extra sugar through urine, while the other helps improve how your body uses insulin and lowers sugar production in the liver. You typically take it as two tablets once a day with your morning meal, starting at a dose of 100 mg of canagliflozin and 1,000 mg of metformin, with a maximum of 300 mg of canagliflozin and 2,000 mg of metformin per day. It's important to know that this medication should not be used if you have severe kidney problems. Additionally, if you take insulin or certain other diabetes medications, you may be at risk for low blood sugar, so monitoring is essential.
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Uses

  • Type 2 diabetes mellitus in adults.
  • Type 2 diabetes mellitus in pediatric patients aged 10 years and older.
  • Reduce risk of major cardiovascular events in adults with type 2 diabetes and cardiovascular disease.
  • Reduce risk of end-stage kidney disease in adults with type 2 diabetes and diabetic nephropathy.
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Dosage

Adults: take INVOKAMET twice daily with meals.
Adults: take INVOKAMET XR once daily with the morning meal.
Pediatric patients aged 10 years and older: dosing based on current regimen.
Maximum daily dose: 300 mg canagliflozin and 2000 mg metformin.
Not recommended for eGFR less than 45 mL/min/1.73 m².
Always follow your doctor's specific instructions for your dose.
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Side effects

Common

Increased urinationUrinary tract infectionsFemale genital infectionsDiarrheaNauseaLactic acidosisLower limb amputation
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Warnings

⚠ Important warnings

  • Not for type 1 diabetes mellitus.
  • Risk of lactic acidosis, especially in renal impairment.
  • Increased risk of lower limb amputation.
  • Monitor renal function before starting.
  • Discontinue before iodinated contrast imaging.
  • Withhold before surgery associated with fasting.
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Drug interactions

  • Carbonic anhydrase inhibitorsincreased risk of lactic acidosisMonitor
  • Drugs that reduce metformin clearanceincreased risk of lactic acidosisMonitor
  • Alcoholmay increase risk of lactic acidosisCaution
  • UGT enzyme inducersmay reduce effectiveness of INVOKAMETCaution
  • Insulin or insulin secretagoguesincreased risk of hypoglycemiaMonitor
  • Digoxinincreased digoxin exposureCaution

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).