MedDataToolLacosamide is a medication used to treat partial-onset seizures and as an additional treatment for primary generalized tonic-clonic seizures in patients aged 4 and older. It works by stabilizing nerve activity in the brain to help prevent seizures. The medication is usually taken twice daily, starting at 100 mg for those using it alone or 50 mg for those using it alongside other treatments, with a maximum dose of 200 mg twice daily. It's important to know that lacosamide can cause serious heart rhythm issues, so monitoring may be necessary. Additionally, if you're taking strong inhibitors of certain liver enzymes, like CYP3A4 or CYP2C9, your dose may need to be adjusted.
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Uses
- Partial-onset seizures in patients 4 years and older.
- Adjunctive therapy for primary generalized tonic-clonic seizures in patients 4 years and older.
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Dosage
Adults: 100 mg twice daily for partial-onset seizures.
Adults: 50 mg twice daily for adjunctive therapy.
Pediatric patients: Dosage based on body weight, administered twice daily.
Adjust dosage based on response, no more than once a week.
Injection: Administered intravenously when oral use is not possible.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Dizzinessheadachenauseasomnolencediplopia
Serious
Suicidal behaviorcardiac rhythm issuessyncopesevere allergic reactions
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Warnings
⚠ Important warnings
- May cause suicidal thoughts or behavior.
- Risk of dizziness and coordination issues.
- Monitor for heart rhythm problems.
- Use caution with drugs affecting heart conduction.
- Not recommended for severe liver impairment.
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Drug interactions
- Strong CYP3A4 or CYP2C9 inhibitorsmay increase lacosamide levelsCaution
- Sodium channel blockersrisk of heart issuesCaution
- Beta-blockersrisk of heart issuesCaution
- Calcium channel blockersrisk of heart issuesCaution
- Potassium channel blockersrisk of heart issuesCaution
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).