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Levothyroxine

Generic: Levothyroxine Sodium

Rx only
Thyroid hormone✓ FDA-verified
View full FDA label ↗
Levothyroxine is a medication used to treat hypothyroidism, a condition where the thyroid gland does not produce enough hormones. It works by providing the body with a synthetic version of a hormone called thyroxine, which helps regulate metabolism and energy levels. You take it as a tablet, usually once a day on an empty stomach, with the starting dose typically being 1.6 micrograms for every kilogram of your body weight, and the maximum dose is generally not more than 300 micrograms per day. It's important to know that this medication should not be taken if you have untreated adrenal insufficiency. Additionally, if you are taking biotin or biotin-containing supplements, you should stop them at least two days before having your thyroid hormone levels checked, as they can interfere with the test results.

Uses

  • Hypothyroidism in adults and children.
  • Thyrotropin suppression in thyroid cancer.

Dosage

Take once daily on an empty stomach, 30 minutes to 1 hour before breakfast.
Pediatric doses vary by age: 10-15 mcg/kg/day for infants, 1.6 mcg/kg/day for older children.
Adjust doses based on age, weight, and other health conditions.
Monitor TSH and T4 levels regularly to ensure proper dosing.
Always follow your doctor's specific instructions for your dose.

Side effects

Common

fatigueincreased appetiteweight lossheat intoleranceheart palpitations

Serious

arrhythmiasmuscle weaknessseizures
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Warnings

⚠ Important warnings

  • Not for weight loss or obesity treatment.
  • May cause serious toxicity if overdosed.
  • Monitor closely if you have heart disease.
  • Stop biotin supplements before thyroid tests.

Drug interactions

  • Calcium carbonatemay reduce levothyroxine absorptionCaution
  • Orlistatmonitor thyroid function changesMonitor
  • Proton pump inhibitorsmay decrease levothyroxine absorptionCaution
  • Phenobarbitalmay reduce levothyroxine effectivenessCaution
  • Amiodaroneinhibits conversion of T4 to T3.Caution

Ask about this drug

Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).