MedDataToolMannitol is a medication used to reduce pressure in the brain and treat swelling in the brain, as well as to lower high pressure in the eyes. It works by drawing water out of cells and into the bloodstream, which helps to decrease swelling and pressure. The medication is given through an intravenous (IV) infusion, usually starting at a dose of 0.25 grams per kilogram of body weight every 6 to 8 hours for brain pressure, or 1.5 to 2 grams per kilogram as a single dose for eye pressure. It's important to know that mannitol should not be used if you have severe kidney problems or are not producing urine. Additionally, it should not be given at the same time as blood products to avoid complications.
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Uses
- Reduction of intracranial pressure.
- Treatment of cerebral edema.
- Reduction of elevated intraocular pressure.
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Dosage
0.25 gram/kg for intracranial pressure every 6 to 8 hours. 1.5 to 2 grams/kg for intraocular pressure as a single dose.
Administer intravenously over at least 30 minutes.
Evaluate renal, cardiac, and pulmonary status before administration.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Hypersensitivity reactions like rash and nauseaFluid and electrolyte imbalances like dehydrationInfusion site reactions including pain and swelling
Serious
Renal failure including acute kidney injuryCNS toxicity such as confusion and seizures
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Warnings
⚠ Important warnings
- Monitor renal, cardiac, and pulmonary function during use.
- Do not use with nephrotoxic drugs to avoid renal failure.
- Avoid using with neurotoxic drugs to prevent CNS toxicity.
- Watch for electrolyte imbalances affecting heart health.
- Discontinue if renal or cardiac status worsens.
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Drug interactions
- Nephrotoxic Drugsincreases risk of renal failureMonitor
- Diureticsmay enhance renal toxicityCaution
- Neurotoxic Drugsmay worsen CNS toxicityCaution
- Drugs affected by electrolyte imbalancesmay cause cardiac issuesCaution
- Renally Eliminated Agentsmay decrease effectivenessCaution
Ask about this drug
Answers pulled from the FDA label only.
Other Brands:
- Osmitrol
- TERUFLEX Blood with Diversion Blood Sampling Arm Anticoagulant CPD with OPTISOL Red Cell Preservative for Collection of 450mL of Blood
- Aridol Bronchial Challenge Test Kit
- Sorbitol-Mannitol
- TERUFLEX Blood Bag System with Diversion Blood Sampling Arm Anticoagulant CPD with OPTISOL Red Cell Preservative Solution for Collection of 500mL of Blood
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).