Metformin is a medication used to help control blood sugar levels in people with type 2 diabetes, especially when diet and exercise alone aren't enough. It works by reducing the amount of sugar your liver produces, decreasing sugar absorption from food, and improving how your body uses insulin. You typically take it as a tablet once a day with your evening meal, starting at a low dose of 500 mg, which can be increased weekly up to a maximum of 2000 mg. A key warning is that it should not be used if you have severe kidney problems, as this can increase the risk of serious side effects. Additionally, if you are taking certain medications that affect kidney function, like carbonic anhydrase inhibitors, you should be cautious and consult your doctor.
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Uses
- Type 2 diabetes mellitus.
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Dosage
Start with 500 mg once daily with the evening meal.
Increase by 500 mg weekly as needed, up to 2000 mg once daily.
If not controlled at 2000 mg once daily, consider 1000 mg twice daily.
Monitor fasting plasma glucose and glycosylated hemoglobin regularly.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Diarrheanauseavomitingflatulenceabdominal discomfortheadacheLactic acidosis
Serious
severe gastrointestinal symptoms
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Warnings
⚠ Important warnings
- Risk of lactic acidosis, especially in those with kidney issues.
- Not recommended for patients with eGFR below 30 mL/min.
- Discontinue before iodinated contrast imaging if eGFR is 30-60 mL/min.
- Not recommended for use in pregnancy or pediatric patients under 17.
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Drug interactions
- Carbonic anhydrase inhibitorsincreased risk of lactic acidosis.Monitor
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
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