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Nesacaine

Generic: Chloroprocaine Hydrochloride

Rx only
Local anestheticAlso: Nesacaine MPF✓ FDA-verified
View full FDA label ↗
Nesacaine is a medication used to numb specific areas of the body for procedures, helping to block pain by stopping nerve signals from reaching the brain. It can be given as a single injection or through a catheter, with starting doses varying based on the procedure but generally not exceeding 800 mg for adults without epinephrine. It's important to know that this medication should only be used by trained healthcare professionals, as improper use can lead to serious complications. Additionally, it should not be used in patients who are allergic to local anesthetics in the PABA ester group. Be cautious if you are taking ergot-type oxytocic drugs, as using these together can cause severe high blood pressure.
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Uses

  • Local anesthesia by infiltration.
  • Peripheral nerve block.
  • Central nerve block.
  • Lumbar epidural block.
  • Caudal epidural block.
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Dosage

Administered as a single injection or continuous infusion.
Maximum dose for adults without epinephrine is 800 mg.
Maximum dose for adults with epinephrine is 1000 mg.
For children over 3 years, maximum dose is 11 mg/kg.
For caudal anesthesia, initial dose is 15 to 25 mL.
Always follow your doctor's specific instructions for your dose.
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Side effects

Common

Restlessnessanxietydizzinessblurred visionTremorsconvulsionsdrowsinessrespiratory arrestHypotensionbradycardiaitchingswellingBackache and headache after lumbar or caudal block

Serious

cardiac arrestAllergic reactions like hives
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Warnings

⚠ Important warnings

  • Only use by trained clinicians.
  • Immediate availability of resuscitation equipment is necessary.
  • Nesacaine should not be used for lumbar or caudal epidural anesthesia.
  • Intra-articular infusions can lead to chondrolysis.
  • Avoid intravascular injection; aspiration is required.
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Drug interactions

  • Epinephrinecan increase toxicity riskCaution
  • Ergot-type oxytocic drugsmay cause severe hypertension.Caution

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Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).