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Pantoprazole

Generic: Pantoprazole Sodium

Rx only
Proton pump inhibitor✓ FDA-verified
View full FDA label ↗
Pantoprazole is a medication used to treat conditions like gastroesophageal reflux disease (GERD) and Zollinger-Ellison Syndrome, which involve excessive stomach acid. It works by blocking the production of stomach acid, helping to relieve symptoms and heal the esophagus. The medication is given through an intravenous injection, with a typical starting dose of 40 mg once daily for GERD, and can go up to 80 mg every 12 hours for Zollinger-Ellison Syndrome. It’s important to know that pantoprazole should not be used if you are allergic to it or similar medications. Additionally, it can interact with clopidogrel, a blood thinner, potentially reducing its effectiveness, so be sure to discuss all medications you are taking with your doctor.
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Uses

  • gastroesophageal reflux disease (GERD). history of erosive esophagitis (EE). pathological hypersecretory conditions.
  • Zollinger-Ellison (ZE) Syndrome.
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Dosage

40 mg once daily for GERD and EE for up to 10 days. 80 mg every 12 hours for ZE Syndrome.
Switch to oral medication as soon as possible.
Discontinue when able to take oral treatment.
Always follow your doctor's specific instructions for your dose.
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Side effects

Common

HeadacheDiarrheaNauseaAbdominal painVomitingFlatulenceDizzinessArthralgiaInjection site reactionsAcute tubulointerstitial nephritisBone fractureLupus erythematosusHepatic effectsHypomagnesemia

Serious

Clostridioides difficile-associated diarrheaSevere dermatologic reactions
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Warnings

⚠ Important warnings

  • Not established for treating upper gastrointestinal bleeding.
  • Potential for exacerbation of zinc deficiency.
  • Risk of acute tubulointerstitial nephritis.
  • Risk of Clostridioides difficile-associated diarrhea.
  • Risk of bone fractures.
  • Risk of severe cutaneous adverse reactions.
  • Risk of lupus erythematosus.
  • Hepatic effects may occur.
  • Monitor for hypomagnesemia.
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Drug interactions

  • Clopidogrelmay reduce effectivenessCaution
  • Warfarinincreased bleeding riskCaution
  • Methotrexatemay elevate toxicityCaution
  • Mycophenolate mofetilreduced effectivenessCaution
  • Antiretroviralsvariable effects on drug levelsCaution

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).