MedDataToolQuetiapine Fumarate is a medication used to treat conditions like schizophrenia and bipolar disorder, including both manic and depressive episodes. It works by affecting certain chemicals in the brain that help regulate mood and thoughts. You can take it as a tablet, either with or without food, starting with a dose of 25 mg twice daily for adults, and the maximum dose can go up to 750 mg per day depending on your needs. It's important to know that this medication is not suitable for individuals who are allergic to it or its ingredients. Additionally, if you're taking strong medications that affect liver enzymes, like ketoconazole, your doctor may need to adjust your quetiapine dose significantly.
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Uses
- Schizophrenia.
- Bipolar I disorder manic episodes.
- Bipolar disorder depressive episodes.
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Dosage
Adults with schizophrenia: Start at 25 mg twice daily, increase to 150–750 mg daily.
Adolescents (13-17 years) with schizophrenia: Start at 25 mg twice daily, increase to 400–800 mg daily.
Adults with bipolar mania: Start at 50 mg twice daily, increase to 400–800 mg daily.
Children (10-17 years) with bipolar mania: Start at 25 mg twice daily, increase to 400–600 mg daily.
Adults with bipolar depression: Start at 50 mg once daily at bedtime, maximum 300 mg daily.
Elderly patients: Start at 50 mg daily, adjust slowly based on response.
Patients with liver issues: Start at 25 mg daily, adjust slowly based on response.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
somnolencedry mouthdizzinessconstipationweight gainincreased mortality in elderly with dementia-related psychosis
Serious
suicidal thoughts
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Warnings
⚠ Important warnings
- Increased risk of death in elderly patients with dementia-related psychosis.
- Increased risk of suicidal thoughts and behaviors in young adults.
- Monitor for worsening symptoms in all ages.
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Drug interactions
- Ketoconazolereduces quetiapine clearance significantlyCaution
- Phenytoinincreases quetiapine clearance up to five timesMonitor
- Divalproexmay decrease quetiapine levels slightlyCaution
- Alcoholmay enhance cognitive and motor effects.Caution
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).