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Rabeprazole

Generic: Rabeprazole Sodium

Rx only
Proton pump inhibitor✓ FDA-verified
View full FDA label ↗
Rabeprazole is a medication used to treat conditions like gastroesophageal reflux disease (GERD), duodenal ulcers, and certain stomach acid-related issues. It works by reducing the amount of acid your stomach produces, helping to relieve symptoms like heartburn and allowing ulcers to heal. You typically take it as a delayed-release tablet, starting with a dose of 20 mg once daily, which can be adjusted based on your needs, but the maximum dose can go up to 60 mg daily for certain conditions. It's important to know that if you have a history of allergic reactions to rabeprazole or similar medications, you should avoid taking it. Additionally, rabeprazole can interact with rilpivirine-containing products, so it's essential to inform your doctor if you are taking any medications in that category.
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Uses

  • Erosive or ulcerative gastroesophageal reflux disease (GERD).
  • Symptomatic GERD.
  • Duodenal ulcers.
  • Helicobacter pylori infection.
  • Pathological hypersecretory conditions.
  • Short-term treatment of symptomatic GERD in adolescents 12 years and older.
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Dosage

  • 20 mg once daily for healing of erosive or ulcerative GERD for 4 to 8 weeks. 20 mg once daily for maintenance of healing of erosive or ulcerative GERD. 20 mg once daily for symptomatic GERD in adults for up to 4 weeks. 20 mg once daily after morning meal for healing of duodenal ulcers for up to 4 weeks. 20 mg with amoxicillin and clarithromycin twice daily for 7 days for H. pylori eradication. 20 mg once daily for up to 8 weeks for symptomatic GERD in adolescents 12 years and older.
  • Always follow your doctor's specific instructions for your dose.
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Side effects

Common

painpharyngitisflatulenceinfectionconstipation in adultsheadachediarrheanauseavomitingabdominal pain in adolescentsacute tubulointerstitial nephritisbone fracturelupus erythematosusvitamin B-12 deficiencyhypomagnesemia

Serious

Clostridium difficile-associated diarrheasevere skin reactions
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Warnings

⚠ Important warnings

  • Not recommended for children under 12 years.
  • Monitor INR and prothrombin time if taking with warfarin.
  • May increase serum levels of methotrexate.
  • Risk of increased digoxin exposure.
  • May reduce absorption of drugs dependent on gastric pH.
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Drug interactions

  • Warfarinincreased INR and bleeding riskCaution
  • Methotrexateelevated serum levels and toxicity riskCaution
  • Digoxinincreased exposure and potential toxicityCaution
  • Clarithromycinserious adverse reactions possibleCaution
  • Antiretroviralsvariable effects on antiviral effectivenessCaution

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).