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Remodulin

Generic: Treprostinil

Rx only
ProstaglandinAlso: Sterile Diluent for Remodulin✓ FDA-verified
View full FDA label ↗
Remodulin is a medication used to treat pulmonary arterial hypertension (PAH), a condition that affects the blood vessels in the lungs and can make it hard to exercise. It works by relaxing and widening the blood vessels, which helps improve blood flow and reduce symptoms. The medication is given as a continuous infusion under the skin or through an intravenous line, starting at a dose of 1.25 ng/kg/min, which can be increased based on how well you respond, with a maximum dose that can go higher depending on your needs. It's important not to stop taking it suddenly, as this can cause serious issues. Additionally, if you have liver problems, you may need a lower starting dose, and be cautious if you are taking medications that affect liver enzymes, like gemfibrozil, as they can increase the levels of Remodulin in your body.
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Uses

  • Pulmonary arterial hypertension (PAH).
  • Symptoms associated with exercise in PAH patients.
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Dosage

Initial dose for new patients: 1.25 ng/kg/min.
Increase based on response, up to 2.5 ng/kg/min per week.
For mild to moderate liver issues, start at 0.625 ng/kg/min.
Continuous subcutaneous infusion is preferred.
Always follow your doctor's specific instructions for your dose.
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Side effects

Common

infusion site painheadachediarrheanauseajaw painhypotension

Serious

severe infusion site reactions
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Warnings

⚠ Important warnings

  • Avoid abrupt cessation of the infusion.
  • Not studied in severe liver issues.
  • Monitor for infections with intravenous use.
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Drug interactions

  • Gemfibrozilincreases treprostinil exposureMonitor
  • Rifampindecreases treprostinil exposureCaution

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Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).