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Sterile Diluent For Remodulin

Generic: Treprostinil

Rx only
ProstaglandinAlso: Remodulin✓ FDA-verified
View full FDA label ↗
Remodulin is a medication used to treat pulmonary arterial hypertension (PAH), a condition that affects blood flow in the lungs and can cause symptoms like shortness of breath during exercise. It works by relaxing blood vessels, which helps improve blood flow and reduce the workload on the heart. The medication is given as a continuous infusion either under the skin or through an intravenous line, starting at a dose of 1.25 nanograms per kilogram per minute, which can be increased based on how well you respond, with a maximum dose not specified. It's important to avoid stopping the infusion suddenly, as this can lead to serious complications. Additionally, if you have liver problems, especially mild to moderate issues, your starting dose should be reduced to 0.625 nanograms per kilogram per minute.
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Uses

  • Pulmonary arterial hypertension (PAH).
  • Symptoms associated with exercise in PAH patients.
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Dosage

Initial dose for new patients: 1.25 ng/kg/min.
Increase dose based on response, up to 2.5 ng/kg/min weekly.
For mild to moderate liver issues, start at 0.625 ng/kg/min.
Transitioning from epoprostenol requires careful dose adjustment.
Always follow your doctor's specific instructions for your dose.
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Side effects

Common

infusion site painheadachediarrheanauseajaw painswellinghypotension

Serious

severe infusion site reactionsinfections
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Warnings

⚠ Important warnings

  • Avoid abrupt stopping of the infusion.
  • Monitor for infections with intravenous use.
  • Use caution in patients with liver issues.
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Drug interactions

  • Gemfibrozilincreases treprostinil exposureMonitor
  • Rifampindecreases treprostinil exposureCaution

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Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).