MedDataToolSynjardy
Generic: Empagliflozin And Metformin Hydrochloride
SGLT2 inhibitor✓ FDA-verified
View full FDA label ↗Synjardy is a medication used to help control blood sugar levels in adults and children aged 10 and older with type 2 diabetes. It combines two ingredients: empagliflozin, which helps the body get rid of excess sugar through urine, and metformin, which lowers sugar production in the liver and improves how the body uses insulin. You take it by mouth, with Synjardy typically twice a day and a starting dose of 10 mg of empagliflozin and 1,000 mg of metformin, with a maximum of 25 mg and 2,000 mg respectively. It's important to know that Synjardy should not be used if you have severe kidney problems. Additionally, if you're taking insulin or certain other diabetes medications, you may be at a higher risk for low blood sugar while using this medication.
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Uses
- Type 2 diabetes mellitus in adults.
- Type 2 diabetes mellitus in pediatric patients aged 10 years and older.
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Dosage
SYNJARDY: 10 mg empagliflozin and 1,000 mg metformin HCl twice daily with meals.
SYNJARDY XR: 10 mg empagliflozin and 1,000 mg metformin HCl once daily with a meal in the morning.
Maximum dosage: 25 mg empagliflozin and 2,000 mg metformin HCl per day.
Not recommended for patients with eGFR less than 45 mL/min/1.73 m².
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
urinary tract infectionsfemale genital infectionsdiarrheanauseavomitinglactic acidosis
Serious
diabetic ketoacidosisvolume depletionlower limb amputation
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Warnings
⚠ Important warnings
- Not for type 1 diabetes; may cause diabetic ketoacidosis.
- Risk of lactic acidosis, especially with renal impairment or certain drugs.
- Not recommended for patients with eGFR less than 30 mL/min/1.73 m².
- Monitor renal function before and during treatment.
- Discontinue before iodinated contrast imaging procedures.
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Drug interactions
- Topiramatemay increase risk of lactic acidosisCaution
- Cimetidinemay increase risk of lactic acidosisCaution
- Alcoholcan enhance metformin's effect on lactate metabolismCaution
- Insulinincreases risk of hypoglycemiaMonitor
- Diureticsmay enhance volume depletionCaution
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).