MedDataToolTizanidine is a medication used to help treat muscle stiffness and spasms in adults. It works by calming the nerves that control muscle movement, which helps reduce tightness. You typically take it by mouth, starting with a dose of 2 mg every 6 to 8 hours as needed, and you can take up to a maximum of 36 mg in a day. It's important to know that tizanidine should not be taken with strong CYP1A2 inhibitors, like fluvoxamine or ciprofloxacin, as this can significantly increase the medication's effects and lead to serious side effects. Additionally, if you have liver problems, you may need to take lower doses, so it's essential to discuss your health history with your doctor.
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Uses
- Spasticity in adults.
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Dosage
Start with 2 mg by mouth every 6 to 8 hours as needed.
Maximum of 3 doses in 24 hours.
Dosage can be increased by 2 mg to 4 mg every 1 to 4 days.
Maximum total daily dosage is 36 mg.
Take consistently with respect to food.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
dry mouthdrowsinessweaknessdizzinesshypotension
Serious
liver injuryhallucinationswithdrawal symptoms
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Warnings
⚠ Important warnings
- Monitor liver function before and after starting treatment.
- Use lower doses in patients with kidney or liver impairment.
- Discontinue slowly to avoid withdrawal symptoms.
- Avoid use with strong CYP1A2 inhibitors.
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Drug interactions
- Fluvoxamineincreases drowsiness and lowers blood pressureMonitor
- Ciprofloxacinincreases drowsiness and lowers blood pressureMonitor
- Oral contraceptivesmay increase tizanidine levelsCaution
- Alcoholincreases sedation effects.Monitor
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).