MedDataToolVoriconazole is an antifungal medication used to treat serious fungal infections, including invasive aspergillosis and certain types of Candida infections. It works by stopping the growth of fungi by interfering with their ability to produce a vital component of their cell membranes. The medication is usually taken as an oral tablet or suspension, starting with a loading dose of 6 mg/kg every 12 hours for the first day, followed by a maintenance dose of 4 mg/kg every 12 hours, with a maximum oral dose of 200 mg every 12 hours. It's important to know that voriconazole can cause liver problems, so regular monitoring of liver function is necessary during treatment. Additionally, voriconazole should not be taken with certain medications like efavirenz, as this can significantly reduce its effectiveness.
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Uses
- Invasive aspergillosis.
- Candidemia in non-neutropenic patients.
- Deep tissue Candida infections.
- Esophageal candidiasis.
- Serious fungal infections from Scedosporium and Fusarium species.
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Dosage
Adults: 6 mg/kg IV every 12 hours for invasive aspergillosis.
Adults: 200 mg orally every 12 hours for candidemia.
Pediatric patients 2 to <12 years: 9 mg/kg IV every 12 hours for invasive aspergillosis.
Pediatric patients 12 to 14 years weighing <50 kg: 4 mg/kg IV every 12 hours.
Adjust doses for liver and kidney impairment.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
visual disturbancesfevernausearashvomitingchills
Serious
liver toxicityarrhythmiassevere skin reactionshallucinations
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Warnings
⚠ Important warnings
- Risk of liver damage and elevated liver tests.
- May cause heart rhythm issues.
- Visual disturbances may occur.
- Not to be used with certain drugs like rifampin and efavirenz.
- Monitor liver function during treatment.
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Drug interactions
- Rifampinsignificantly reduces voriconazole effectivenessCaution
- Efavirenzreduces voriconazole levelsCaution
- Phenytoinreduces voriconazole levelsCaution
- Fluconazoleincreases voriconazole levelsMonitor
- John's Wortsignificantly reduces voriconazole effectivenessCaution
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).