MedDataToolCanagliflozin is a medication used to help adults with type 2 diabetes manage their blood sugar levels and reduce the risk of serious heart and kidney problems. It works by preventing the kidneys from reabsorbing glucose back into the blood, which helps lower blood sugar levels by allowing more glucose to be excreted in urine. You take it as a pill once a day, starting with a dose of 100 mg before your first meal, which can be increased to a maximum of 300 mg if needed. It's important to know that this medication is not recommended for people with type 1 diabetes or those with severe kidney problems. Additionally, if you're taking insulin or certain other diabetes medications, you may be at a higher risk for low blood sugar when using canagliflozin.
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Uses
- Type 2 diabetes mellitus.
- Cardiovascular disease.
- End-stage kidney disease.
- Diabetic nephropathy with albuminuria.
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Dosage
Start with 100 mg once daily before the first meal.
May increase to 300 mg once daily if needed.
Assess kidney function before starting.
Adjust dose for kidney impairment as needed.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Increased urinationUrinary tract infectionsFemale genital infectionsLower limb amputationDiabetic ketoacidosis
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Warnings
⚠ Important warnings
- Not for type 1 diabetes.
- Not for eGFR less than 30 mL/min/1.73 m².
- Risk of dehydration and low blood pressure.
- Monitor for kidney function changes.
- Increased risk of genital infections.
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Drug interactions
- Rifampinmay reduce INVOKANA effectivenessCaution
- Insulinincreased risk of low blood sugarMonitor
- Digoxinincreased digoxin exposureCaution
- Lithiummay decrease lithium levelsCaution
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).