MedDataToolEstradiol Vaginal Cream is a medication used to treat moderate to severe symptoms of vulvar and vaginal atrophy due to menopause, which can include dryness and discomfort. It works by replacing estrogen, a hormone that decreases after menopause, helping to restore the vaginal lining and relieve symptoms. You typically apply 2 to 4 grams of the cream daily for one or two weeks, then reduce the dose to 1 gram one to three times a week as needed. It's important to know that this medication should not be used if you have unexplained vaginal bleeding or a history of certain cancers. Additionally, be cautious if you're taking medications that affect liver enzymes, such as St. John's Wort, as they can alter how well the cream works.
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Uses
- Moderate to severe vulvar atrophy.
- Moderate to severe vaginal atrophy.
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Dosage
2 to 4 g daily for one or two weeks.
Then reduce to half the initial dose for a similar period. 1 g one to three times a week after symptoms improve.
Use for the shortest duration necessary.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Burning or irritation at the application siteVaginal discomfort or itchingNausea or vomitingHeadaches or migraines
Serious
Increased risk of blood clots or stroke
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Warnings
⚠ Important warnings
- Increased risk of endometrial cancer in women with a uterus.
- Not for preventing cardiovascular disease or dementia.
- May cause abnormal bleeding or spotting.
- Monitor for signs of stroke or blood clots.
- Evaluate for malignancy if abnormal bleeding occurs.
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Drug interactions
- John's Wortmay reduce estrogen effectivenessCaution
- Erythromycinmay increase estrogen levelsCaution
- Grapefruit juicemay increase estrogen levelsCaution
- Phenobarbitalmay reduce estrogen effectivenessCaution
- Carbamazepinemay reduce estrogen effectivenessCaution
Ask about this drug
Answers pulled from the FDA label only.
Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).