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Invega

Generic: Paliperidone Palmitate

Rx only
Atypical antipsychoticAlso: INVEGA SUSTENNA✓ FDA-verified
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Invega is a medication used to treat schizophrenia and schizoaffective disorder in adults. It works by balancing certain chemicals in the brain that affect mood and behavior. The medication is given as an injection by a healthcare professional, starting with a dose of 234 mg on the first day and 156 mg one week later, followed by monthly doses that can range from 39 mg to 234 mg. It is important to know that Invega should not be used if you are allergic to paliperidone or risperidone. Additionally, if you are taking strong medications that can affect liver enzymes, like carbamazepine, you should be cautious, as they may lower the effectiveness of Invega.

Uses

  • Schizophrenia in adults.
  • Schizoaffective disorder in adults.

Dosage

Administered by a healthcare professional only.
Initial dose for schizophrenia: 234 mg on Day 1, 156 mg on Day 8.
Monthly maintenance dose for schizophrenia: 117 mg.
Initial dose for schizoaffective disorder: 234 mg on Day 1, 156 mg on Day 8.
Monthly maintenance dose for schizoaffective disorder: adjust based on tolerability.
Always follow your doctor's specific instructions for your dose.

Side effects

Common

injection site reactionssomnolencedizzinessakathisiaextrapyramidal disorderincreased mortality in elderly with dementia-related psychosis

Serious

strokeneuroleptic malignant syndrome
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Warnings

⚠ Important warnings

  • Increased mortality in elderly patients with dementia-related psychosis.
  • Not approved for dementia-related psychosis.
  • Caution in patients with renal impairment.
  • Monitor for orthostatic hypotension.
  • Avoid strong CYP3A4/P-gp inducers.

Drug interactions

  • Carbamazepinemay decrease paliperidone levelsCaution
  • Rifampinmay decrease paliperidone levelsCaution
  • John's Wortmay decrease paliperidone levelsCaution
  • Levodopamay reduce its effectiveness.Caution

Ask about this drug

Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).