MedDataToolRivaroxaban is a medication used to prevent blood clots and reduce the risk of stroke in people with certain heart conditions, as well as to treat conditions like deep vein thrombosis and pulmonary embolism. It works by blocking a specific protein in your blood that helps it to clot, which can help prevent dangerous clots from forming. You typically take it as a tablet, with a starting dose of 15 mg twice daily for the first 21 days, followed by 20 mg once daily, and it should be taken with food. A key warning is that it should not be taken if you have active bleeding or a severe allergic reaction to it. Additionally, using nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or aspirin can increase the risk of bleeding when taking this medication.
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Uses
- Reduce risk of stroke in nonvalvular atrial fibrillation.
- Treatment of deep vein thrombosis (DVT).
- Treatment of pulmonary embolism (PE).
- Reduce risk of recurrent DVT or PE.
- Prophylaxis of DVT after knee or hip replacement surgery.
- Prophylaxis of venous thromboembolism (VTE) in acutely ill medical patients.
- Reduce risk of major cardiovascular events in coronary artery disease (CAD).
- Reduce risk of major thrombotic events in peripheral artery disease (PAD).
- Treatment of VTE in pediatric patients.
- Thromboprophylaxis in pediatric patients with congenital heart disease after Fontan procedure.
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Dosage
15 mg twice daily for 21 days, then 20 mg once daily for DVT and PE. 10 mg once daily for DVT prophylaxis after surgery. 10 mg once daily for VTE prophylaxis in acutely ill patients. 2.5 mg twice daily with aspirin for CAD or PAD.
Pediatric dosing varies by weight and age.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
BleedingCoughVomitingGastroenteritisSpinal/epidural hematoma
Serious
Increased risk of stroke after discontinuation
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Warnings
⚠ Important warnings
- Premature discontinuation increases risk of thrombotic events.
- Risk of spinal/epidural hematoma with neuraxial anesthesia.
- Monitor for neurological impairment after spinal procedures.
- Avoid use in patients with severe renal impairment.
- Use caution with drugs affecting hemostasis.
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Drug interactions
- Warfarinincreased bleeding riskCaution
- Aspirinincreased bleeding riskCaution
- Clopidogrelincreased bleeding riskCaution
- NSAIDsincreased bleeding riskCaution
- Strong CYP3A inhibitorsincreased rivaroxaban exposureCaution
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).