MedDataToolValsartan
Generic: Sacubitril And Valsartan
Angiotensin II receptor blockerAlso: ENTRESTO✓ FDA-verified
View full FDA label ↗Valsartan is a medication used to help reduce the risk of heart-related deaths and hospitalizations in adults with chronic heart failure, and it also treats heart failure in children aged one year and older. It works by blocking certain chemicals in the body that can cause blood vessels to narrow, helping to relax the blood vessels and improve blood flow. Adults typically start with a dose of 49 mg taken twice a day, which can be increased to a maximum of 97 mg twice daily as tolerated. It's important to know that this medication should not be taken with ACE inhibitors, as this combination can cause serious side effects. If you have kidney problems or are switching from an ACE inhibitor, be sure to discuss this with your doctor, as your starting dose may need to be adjusted.
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Uses
- Reduce risk of cardiovascular death in adults with chronic heart failure.
- Reduce hospitalization for heart failure in adults.
- Treat symptomatic heart failure in pediatric patients aged one year and older.
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Dosage
Adults start at 49 mg/51 mg twice daily, target 97 mg/103 mg.
Adjust adult doses every 2 to 4 weeks as tolerated.
Pediatric dosing varies by weight; see prescribing information.
Reduce starting dose for patients not on ACE inhibitors or ARBs.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
hypotensioncoughdizziness
Serious
hyperkalemiarenal failureangioedemaimpaired renal functionsevere hypotension
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Warnings
⚠ Important warnings
- Discontinue if pregnancy is detected due to fetal toxicity.
- Contraindicated with ACE inhibitors and aliskiren in certain patients.
- Monitor renal function with NSAIDs and potassium-sparing diuretics.
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Drug interactions
- Aliskirencontraindicated in patients with diabetesAvoid
- Potassium-sparing diureticsmay increase serum potassiumCaution
- NSAIDsmay worsen renal functionCaution
- Lithiumincreased risk of toxicityMonitor
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).