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Estradiol

Generic: Levonorgestrel And Ethinyl Estradiol

Rx only
Combined oral contraceptiveAlso: Iclevia✓ FDA-verified
View full FDA label ↗
Estradiol is a medication used to help prevent pregnancy in women of reproductive age. It works by stopping the ovaries from releasing eggs, which means there’s no egg available for sperm to fertilize. You take it as a tablet, one pill daily at the same time for 91 days, starting with the first white tablet on a Sunday after your period begins, with a maximum of one tablet a day. It's important to know that if you smoke and are over 35 years old, this medication may not be safe for you. Additionally, you should avoid using it if you are taking certain hepatitis C medications that include ombitasvir, paritaprevir, and ritonavir, as this can lead to serious side effects.
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Uses

  • prevent pregnancy.
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Dosage

Take one tablet daily by mouth at the same time for 91 days.
Start on a Sunday after your period begins.
Use additional contraception for the first 7 days if starting new.
Follow the order on the Extended-Cycle Wallet.
Take one green tablet daily for the last 7 days.
Always follow your doctor's specific instructions for your dose.
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Side effects

Common

headachenauseaacnebreast tendernessweight gaindepressioncardiovascular events

Serious

strokeliver disease
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Warnings

⚠ Important warnings

  • Do not use if you smoke and are over 35 years old.
  • Increased risk of serious cardiovascular events with smoking.
  • Use caution if switching from other contraceptives.
  • Not recommended for women who are breastfeeding.
  • Consider the possibility of pregnancy before starting.
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Drug interactions

  • Aprepitantmay decrease effectivenessCaution
  • Carbamazepinemay decrease effectivenessCaution
  • Rifampinmay decrease effectivenessCaution
  • John's wortmay decrease effectivenessCaution
  • Colesevelammay decrease effectiveness of ethinyl estradiol.Caution

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Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).