MedDataToolItraconazole is a medication used to treat various fungal infections, including blastomycosis, histoplasmosis, aspergillosis, and onychomycosis (fungal nail infections). It works by stopping the growth of fungi by disrupting their cell membranes. The medication is taken in capsule form, typically starting at a dose of 200 mg once daily, which can be increased to a maximum of 400 mg daily if needed. A key warning is that itraconazole should not be used in patients with congestive heart failure, as it can worsen this condition. Additionally, it should not be taken with certain medications like methadone, as this can lead to serious heart issues.
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Uses
- Blastomycosis, pulmonary and extrapulmonary.
- Histoplasmosis, including chronic cavitary pulmonary disease.
- Aspergillosis, pulmonary and extrapulmonary.
- Onychomycosis of the toenail.
- Onychomycosis of the fingernail.
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Dosage
200 mg once daily for blastomycosis and histoplasmosis. 200 mg once daily for toenail onychomycosis for 12 weeks. 200 mg twice daily for fingernail onychomycosis in pulses.
Take with a full meal for best absorption.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Nauseavomitingdiarrheaabdominal painFatigueheadachedizzinessRashpruritusLife-threatening heart issues with certain drugs
Serious
elevated liver enzymesSerious liver problemsincluding liver failure
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Warnings
⚠ Important warnings
- Do not use if you have heart failure or ventricular dysfunction.
- Risk of serious liver damage; monitor liver function.
- Caution in patients with kidney or liver impairment.
- Avoid use with certain heart medications.
- Discontinue if signs of heart failure occur.
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Drug interactions
- Methadonecontraindicated during treatmentAvoid
- Disopyramidecontraindicated during treatmentAvoid
- Dofetilidecontraindicated during treatmentAvoid
- Quinidinecontraindicated during treatmentAvoid
- Ergot alkaloidscontraindicated during treatmentAvoid
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).