MedDataToolPaliperidone is a medication used to treat schizophrenia and schizoaffective disorder, helping to manage symptoms by affecting certain chemicals in the brain that influence mood and behavior. It comes in the form of extended-release tablets, which should be taken once daily, starting at a dose of 6 mg for adults, with a maximum dose of 12 mg. It's important to swallow the tablets whole without chewing or crushing them. Patients who are allergic to paliperidone or risperidone should not take this medication. Additionally, if you are taking risperidone, be cautious, as paliperidone is a major active form of that drug and can increase exposure to its effects.
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Uses
- Schizophrenia.
- Schizoaffective disorder.
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Dosage
Adults with schizophrenia: Start at 6 mg once daily, can adjust between 3 to 12 mg.
Adolescents (12-17 years) with schizophrenia: Start at 3 mg once daily, can adjust between 3 to 12 mg.
Adults with schizoaffective disorder: Start at 6 mg once daily, can adjust between 3 to 12 mg.
Take tablets whole with liquids; do not chew or crush.
Can be taken with or without food.
Always follow your doctor's specific instructions for your dose.
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Side effects
Common
Extrapyramidal symptomstachycardiaakathisiasomnolenceweight gainIncreased mortality in elderly with dementia-related psychosis
Serious
strokeneuroleptic malignant syndrome
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Warnings
⚠ Important warnings
- Increased risk of death in elderly patients with dementia-related psychosis.
- Not approved for treating dementia-related psychosis.
- Risk of stroke in elderly patients with dementia-related psychosis.
- May cause orthostatic hypotension leading to dizziness or fainting.
- Use caution with other CNS depressants like alcohol.
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Drug interactions
- Carbamazepinemay require dose increase of paliperidoneCaution
- Divalproex sodiumincreases paliperidone levels by about 50%Monitor
- Levodopapaliperidone may reduce its effectiveness.Caution
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Answers pulled from the FDA label only.
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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).