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Sterile Diluent

Generic: Treprostinil

Rx only
ProstaglandinAlso: Sterile Diluent for Treprostinil✓ FDA-verified
View full FDA label ↗
Treprostinil injection is a medication used to treat pulmonary arterial hypertension (PAH), a condition that affects blood flow in the lungs and can cause symptoms like shortness of breath during exercise. It works by relaxing and widening blood vessels, which helps improve blood flow and reduce the symptoms of PAH. The medication is given as a continuous infusion either under the skin or through an intravenous line, starting at a dose of 1.25 ng/kg/min, which can be increased based on how well you respond, with a maximum dose that can go higher depending on your needs. It's important to avoid stopping the medication suddenly, as this can lead to serious health issues. Additionally, if you are taking gemfibrozil, a medication used to lower cholesterol, it can significantly increase the levels of treprostinil in your body, so your doctor will need to monitor you closely.

Uses

  • Pulmonary arterial hypertension (PAH).

Dosage

Initial dose for new patients: 1.25 ng/kg/min.
Increase dose based on response, up to 2.5 ng/kg/min per week after 4 weeks.
For mild to moderate liver issues, start at 0.625 ng/kg/min.
For patients transitioning from epoprostenol, adjust treprostinil dose gradually.
Always follow your doctor's specific instructions for your dose.

Side effects

Common

infusion site painheadachediarrheanauseajaw painhypotension

Serious

severe infusion site reactionsinfections
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Warnings

⚠ Important warnings

  • Avoid abrupt cessation of the infusion.
  • Use caution in patients with liver issues.
  • Monitor for infections with intravenous use.

Drug interactions

  • Gemfibrozilincreases treprostinil exposureMonitor
  • Rifampindecreases treprostinil exposure.Caution

Ask about this drug

Answers pulled from the FDA label only.

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Medical Disclaimer: This content is provided for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider before taking any medication.
Data Source: Publicly available drug labeling information from the U.S. Food and Drug Administration (FDA).